Select a cantaloupe that feels heavy for its size, has a tan or golden rind, and gives slightly when pressed at the blossom end. It should have a mild, sweet smell.
Cut the cantaloupe in half from top to bottom. Use a large spoon to scrape out the seeds and loose fibers without removing the firm orange flesh.
Slice the cantaloupe into wedges. Remove the rind, then cut the flesh into pieces about 1 inch wide. Measure 3 cups.
Measure the Greek yogurt, orange juice, lime juice, ice, and salt. Keep the honey aside until after the first taste.
Pour the orange juice and lime juice into the blender. Spoon the Greek yogurt on top.
Add the cantaloupe cubes, salt, and ice. Keep the ingredients below the blender’s maximum-fill line.
Blend on low speed for 10 seconds. Increase to high speed and blend for 30 to 45 seconds, or until smooth. Stop and scrape down the sides if needed.
Taste the smoothie. Blend in 1 teaspoon honey for more sweetness or 1/2 teaspoon lime juice for more brightness. Add extra orange juice 1 tablespoon at a time if the smoothie is too thick.
Divide the smoothie between two glasses. Garnish with cantaloupe or lime, if desired, and serve within 10 minutes.
